Fig. S7.

Map of the electrostatic potential of the model structure of procaspase-6 built from the zymogen crystal structures (PDB ID codes 4iyr and 3NR2). The missing residues of each PDB template structure were built by de novo modeling using Chimera/Modeler platform. The electrostatic potential map (red, acidic regions; blue, basic regions; white, hydrophobic/neutral regions) was generated using PyMOL Molecular Graphics System (Schrödinger, LLC). Highlighted are key regions of caspase-6 that undergo statically significant changes in the H/D exchange along caspase-6 proteolytic activation.