Table S2.
General demographics and histopathology of patients with pancreatic cancer by KRAS status
| Pancreatic cancer with detectable KRAS, n = 66 | Pancreatic cancer with undetectable KRAS, n = 155 | P value | |
| Age, y, mean ± SD | 66.2 ± 10.8 | 67.3 ± 10.3 | 0.473 |
| Gender, n (%) | 0.070 | ||
| Male | 30 (24.8) | 91 (75.2) | |
| Female | 36 (36.0) | 64 (64.0) | |
| Race, n (%) | 0.889 | ||
| White | 55 (29.3) | 133 (70.7) | |
| African-American | 1 (25.0) | 3 (75.0) | |
| Hispanic | — | 1 (100.0) | |
| Asian | 5 (41.7) | 7 (58.3) | |
| Other or unknown | 2 (40.0) | 3 (60.0) | |
| Classic symptoms of PDAC, n (%) | 0.194 | ||
| Absent | 49 (27.8) | 127 (72.2) | |
| Present | 17 (37.8) | 28 (62.2) | |
| Abdominal pain, n (%) | 0.361 | ||
| Absent | 41 (32.3) | 86 (67.7) | |
| Present | 25 (26.6) | 69 (73.4) | |
| Jaundice, n (%) | 0.528 | ||
| Absent | 35 (31.8) | 75 (68.2) | |
| Present | 31 (27.9) | 80 (72.1) | |
| Tumor size, cm, median (IQR) | 3.5 (3.0–4.5) | 2.7 (2.2–3.5) | 0.002 |
| Tumor size, n (%) | 0.004 | ||
| ≤ 1.00 cm | — | 2 (100.0) | |
| 1.01–1.50 cm | 5 (22.7) | 17 (77.3) | |
| 1.51–2.00 cm | 2 (16.7) | 10 (83.3) | |
| 2.01–2.50 cm | 4 (8.5) | 43 (91.5) | |
| 2.51–3.00 cm | 12 (31.6) | 26 (68.4) | |
| 3.01–3.50 cm | 15 (41.7) | 21 (58.3) | |
| 3.51–4.00 cm | 10 (45.5) | 12 (54.6) | |
| >4.01 cm | 18 (42.9) | 24 (57.1) | |
| AJCC T stage, n (%) | 0.003 | ||
| T1 | 5 (22.7) | 17 (77.3) | |
| T2 | 5 (10.9) | 41 (89.1) | |
| T3 | 56 (36.6) | 97 (63.4) | |
| AJCC N stage, n (%) | 0.004 | ||
| N0 | 7 (13.7) | 44 (86.3) | |
| N1 | 59 (34.7) | 111 (65.3) | |
| AJCC M stage, n (%) | |||
| M0 | 66 (29.9) | 155 (70.2) | — |
| M1 | — | ||
| AJCC stage, n (%) | 0.013 | ||
| IA | 3 (25.0) | 9 (75.0) | |
| IB | — | 17 (100.0) | |
| IIA | 4 (18.2) | 18 (81.8) | |
| IIB | 59 (34.7) | 111 (65.3) | |
| Grade of tumor differentiation, n (%) | 0.118 | ||
| Well/moderately differentiated | 37 (26.2) | 104 (79.8) | |
| Poorly differentiated | 29 (36.3) | 51 (63.7) | |
| Perineural invasion, n (%) | 0.086 | ||
| Absent | 4 (15.4) | 22 (84.6) | |
| Present | 62 (31.8) | 133 (68.2) | |
| Lymphovascular invasion, n (%) | 0.078 | ||
| Absent | 17 (22.4) | 59 (77.6) | |
| Present | 49 (33.8) | 96 (66.2) | |
| Number of harvested nodes, median (IQR) | 20 (17–28) | 19 (14–27) | 0.047 |
| Number of harvested nodes, n (%) | 0.355 | ||
| ≤20 nodes | 30 (27.0) | 81 (73.0) | |
| >20 nodes | 36 (32.7) | 74 (67.3) | |
| Number of positive nodes, median (IQR) | 4.0 (2.0–7.0) | 1 (0.0–4.0) | <0.001 |
| Positive nodes, n (%) | 0.004 | ||
| Absent | 7 (13.7) | 44 (86.3) | |
| Present | 59 (34.7) | 111 (65.3) |