Fig. S3.

Electrostatic potential map of HsPRMT5/MEP50 protomer reveals potential allosteric sites. (A) The protomer of HsPRMT5/MEP50 (PDB ID code: 4GQB) is shown; the beige subunit represents PRMT5, while the brown subunit represents MEP50. The active site is highlighted by a solid black enclosure. (B) Dashed black enclosures on the opposite face of the structure in A indicate negatively charged cavities as potential allosteric binding sites on the electrostatic potential map, generated using APBS in PyMOL (red to blue corresponds to −5 kT/e to 5 kT/e).