Fig. 5.

The effects of increasing differences in host and donor thymic self-peptides on alloreactivity percentages in the RICE model. The simulation was performed with an original cohort of ${10}^5$ TCRs, of which $50\%$ survived selection under ${10}^4$ self-peptides ($E_n=11.52$). Increasing numbers of nonnative peptides [either random (black curves) or single-difference mutants (red curves)] were introduced, and the numbers of TCRs reacting to these were recorded. The theoretical estimate is from Eq. 16, with single-TCR recognition probabilities for random and single-mutant peptide taken from Fig. 4 A and B.