Fig. 3.

The superiority of PLR-ZnT8 immobilized on pGOLD for ZnT8A detection. Scatterplot and ROC analysis of ZnT8A levels detected by different ZnT8-related antigens immobilized on pGOLD in 307 human serum samples from 138 T1D patients and 169 healthy individuals provided by the IASP and University of Florida. The assay performance was ∼76% sensitivity and ∼97% specificity for PLR-ZnT8, ∼2% sensitivity and ∼94% specificity for DS-ZnT8, and ∼59% sensitivity and ∼94% specificity for CTD. All antigens used were of the 325R variant.