TABLE 3.

The effect of age on the mean percent change in serum lipid levels of postmenopausal women treated with ospemifene 60 mg from studies 15-50718,²⁵ 1506002,^16,33 15-50615,³⁴ 15-50310²¹/15-50310x,²² and 15-50821^23,24

		Mean percent change from baseline (n)
		Age < 60 y			Age ≥60 y
	Time point, mos	Ospemifene 60 mg (n = 664)	Placebo (n = 545)	P	Ospemifene 60 mg (n = 578)	Placebo (n = 379)	P
HDL	3	3.5608 (498)	0.4212 (418)	0.0005	5.2473 (479)	−0.0429 (297)	<0.0001
	6	3.7713 (162)	4.4413 (43)	0.7886	6.1076 (212)	−0.9000 (52)	0.0027
	12	2.4799 (150)	−1.0935 (40)	0.1614	2.1321 (192)	−2.5890 (48)	0.0204
LDL	3	−4.5125 (263)	2.9522 (163)	<0.0001	−5.7298 (301)	1.8122 (145)	0.0010
	6	−5.2666 (160)	3.3872 (43)	0.0144	−7.8387 (212)	1.5365 (52)	0.0075
	12	−6.4397 (148)	−3.3896 (40)	0.3080	−7.3690 (192)	−1.0783 (48)	0.0525
Triglycerides	3	10.7017 (498)	8.0056 (418)	0.2944	9.1318 (479)	9.4436 (297)	0.9086
	6	17.0465 (162)	19.8375 (43)	0.6828	12.7093 (212)	18.5546 (52)	0.3768
	12	12.6197 (150)	15.7714 (40)	0.6416	13.8306 (192)	19.1875 (48)	0.3778
Total cholesterol	3	−0.655 (498)	0.0740 (418)	0.3649	−1.5039 (479)	−0.4904 (297)	0.3652
	6	−1.2853 (162)	3.4364 (43)	0.0473	−2.2008 (212)	0.1701 (52)	0.2919
	12	−2.7399 (150)	−2.0868 (40)	0.7407	−3.1654 (192)	−1.1288 (48)	0.325

HDL, high-density lipoprotein; LDL, low-density lipoprotein.