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. 2017 May 17;8(37):60809–60825. doi: 10.18632/oncotarget.17955

Figure 7.

Figure 7

A-B: Identification of over-represented transcription factor binding sites (TFBS) in sets of differentially expressed genes in hepatic E and splenic F tissue by oPOSSUM. Members of the ETS transcription factor family (blue diamonds), key regulators of the hypertrophic transcriptional program (orange diamonds), signaling transducer and activator of transcription 3, (STAT3, green diamond), AT-Rich Interaction Domain 3 (ARID3A, green diamond), Nkx2-5 (red diamond) and kruppel-like factor 4 (Klf4, red diamond) binding sites are highlighted within the promoter regions. Binding sites for SPIB, Nkx2-5 and Klf4 are specifically enriched in the promoter regions of differentially regulated genes in both organs (liver and spleen) after MI. C. Rank test of selected transcription factors based on the fisher exact test score for liver and spenic tissue. A rank% value of 100 indicates that the mentioned TF are most probably functionally relevant. A rank% value of < 70 indicates that these TF may not be involved in gene regulation. Klf4 shows high values in both tissue types, comparable to those in the myocardial infarct core zone.