Table 2g. Methylation patterns of CpG sites on matrix metallo proteinase between Kawasaki disease patients and control subjects.

Target ID	Symbol	Fold-Change	p-value	Fold-Change	p-value	Fold-Change	p-value
		(KD1 vs. HC)	(KD1 vs. HC)	(KD1 vs. FC)	(KD1 vs. FC)	(KD3 vs. KD1)	(KD3 vs. KD1)
cg19612376	MMP25	-1.004	0.237	1.001	0.789	-1.003	0.295
cg22053861		-1.004	0.061	-1.002	0.255	-1.001	0.490
cg23531828		1.002	0.867	-1.012	0.181	-1.014	0.125
cg25584355		1.001	0.585	-1.005	0.008*	1.001	0.496
cg26705553		-1.006	0.001*	1.009	0.000*	-1.003	0.172
cg26942943		-1.006	0.006*	-1.002	0.444	1.010	0.000*
cg02706104	MMP26	-1.005	0.147	1.000	0.990	-1.038	0.000*
cg05316601		-1.013	0.000*	-1.003	0.334	-1.030	0.000*
cg09805271		-1.013	0.176	-1.009	0.335	-1.104	0.000*
cg12493906		-1.028	0.000*	-1.008	0.143	1.017	0.002*
cg17992177		-1.018	0.001*	-1.006	0.261	-1.032	0.000*
cg23389785		-1.009	0.015*	-1.006	0.108	1.000	0.943
cg06259570	MMP27	-1.012	0.012*	-1.011	0.019*	-1.037	0.000*
cg09758894		-1.011	0.015*	1.008	0.082	-1.015	0.001*
cg13252516		1.003	0.329	1.006	0.080	-1.038	0.000*
cg18932968		-1.003	0.302	1.013	0.000*	-1.025	0.000*
cg25277638		-1.024	0.039*	-1.009	0.456	1.004	0.730
cg01134296	MMP28	-1.024	0.000*	-1.019	0.000*	1.020	0.000*
cg01352921		-1.001	0.304	-1.002	0.201	1.004	0.001*
cg01622018		-1.062	0.000*	-1.022	0.046*	1.018	0.091
cg04790749		-1.004	0.614	1.009	0.273	-1.063	0.000*
cg07330075		-1.005	0.184	1.009	0.021*	-1.029	0.000*
cg07546558		1.009	0.002*	1.008	0.003*	-1.011	0.000*
cg07916589		-1.005	0.231	1.006	0.164	1.004	0.378
cg09357580		1.004	0.004*	1.003	0.031*	-1.003	0.018*
cg09730211		1.003	0.143	1.007	0.003*	-1.014	0.000*
cg09807148		-1.014	0.000*	-1.002	0.444	-1.002	0.501
cg12700449		-1.028	0.000*	-1.017	0.001*	-1.001	0.893
cg13326172		1.001	0.460	-1.005	0.001*	1.005	0.001*
cg16246294		1.002	0.486	1.014	0.000*	-1.015	0.000*
cg25172682		1.018	0.095	1.009	0.415	-1.042	0.000*

For simplicity, we listed the p values only to 10-3. Actually, the CpG marker cg10505873 (the target for further examination) has p value < 10-5 among all of the three comparisons (KD1 vs. FC, KD1 vs. HC and KD3 vs. KD1). When examined with the FDR (with Bonferroni correction), cg10505873 is also significant among the three comparisons.

KD1: Kawasaki disease before IVIG treatment; KD3: Kawasaki disease > 3 weeks after IVIG treatment; FC: febrile control; HC: healthy control.