Figure 3. Effects of a combination of BNTX and TRAIL on the Bcl-2 protein family, IAP protein family, MAPKs, and AKT signaling molecules in AsPC-1 cells.

(A, B) AsPC-1 cells were exposed to TRAIL (25 ng/ml) with or without BNTX (2.5 μM) for 24 h, lysed, and analyzed by western blot analysis using the indicated antibodies. The results are representative of three independent experiments. The arrows indicate the three major isoforms of Bim, including BimEL, BimL, and BimS.