Table 2. Cox proportional hazards regression analysis of overall survival in TCGA dataset, including gender, age, TNM stage and gene expression (n=375).
| Factors | Univariate cox regression | Multivariate cox regression | |||||||
|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | ||||
| Gender | M/F | 1.0871 | 0.6902-1.712 | 0.719 | 0.9357 | 0.5726-1.529 | 0.790835 | ||
| Age | 1.028 | 1.009-1.048 | 0.0038 | * | 1.0385 | 1.0171-1.0604 | 0.000373 | * | |
| Stage | II/I | 1.084 | 0.3928-2.99 | 0.876652 | 0.966 | 0.344-2.7107 | 0.947 | ||
| III/I | 3.007 | 1.1636-7.772 | 0.023043 | * | 2.789 | 1.0258-7.5823 | 0.044444 | * | |
| IV/I | 5.644 | 2.1162-15.051 | 0.000545 | * | 6.026 | 2.1317-17.0328 | 0.000705 | * | |
| gr§ | Low/High | 1.6626 | 1.035-2.671 | 0.0357 | * | 0.6903 | 0.3116-1.5294 | 0.361205 | |
| CPT2 | 0.9985 | 0.9977-0.9993 | 0.000251 | * | 0.9984 | 0.9973-0.9995 | 0.004131 | * | |
| ACADM | 0.9989 | 0.9982-0.9996 | 0.00318 | * | 0.9999 | 0.999-1.0007 | 0.775074 | ||
| ACAA2 | 0.9997 | 0.9995-0.9999 | 0.00577 | * | 0.9998 | 0.9995-1 | 0.068882 | ||
| ACAA1 | 1 | 0.9994-1 | 0.884 | 1 | 0.9995-1.0008 | 0.654016 | |||
| ACADS | 0.9996 | 0.9992-1 | 0.149 | 1 | 0.9999-1.0011 | 0.127275 | |||
| ACSS2 | 0.9999 | 0.9997-1 | 0.469 | 0.9998 | 0.9996-1 | 0.111654 | |||
| ACSF2 | 1 | 0.9993-1 | 0.928 | 1 | 0.9992-1.0009 | 0.975314 | |||
§Samples were divided into two groups based on the hierarchical clustering of gene expression of the 7 fatty acid metabolic associated genes (gr). *p<0.05. HR: hazard ratio; CI: confidence interval.