Table 1. Subgroup analyses of methylated P16 and RASSF1A genes.
| Gene | Subgroups | Studies | OR (95% CI) | Heterogeneity (I2; P) | P value | Cases | Controls |
|---|---|---|---|---|---|---|---|
| P16 | |||||||
| Ethnicity | |||||||
| Caucasians | 7 | 6.32 (1.56 - 25.53) | 72.6%; 0.001 | 0.01 | 660 | 606 | |
| Asians | 4 | 11.65 (3.58 - 37.95) | 25.2%; 0.260 | < 0.001 | 180 | 194 | |
| Method | |||||||
| MSP | 8 | 4.49 (1.93 - 10.45) | 45.7%; 0.075 | < 0.001 | 347 | 312 | |
| QMSP | 3 | 46.43 (11.31 - 190.58) | 0.0%; 0.902 | < 0.001 | 493 | 488 | |
| RASSF1A | |||||||
| Ethnicity | |||||||
| Caucasians | 6 | 40.13 (20.51 - 78.54) | 0.0%; 0.593 | < 0.001 | 810 | 551 | |
| Asians | 3 | 18.89 (8.04 - 44.39) | 0.0%; 0.580 | < 0.001 | 170 | 182 | |
| Method | |||||||
| MSP | 3 | 17.01 (6.93 - 41.78) | 2.8%; 0.358 | < 0.001 | 161 | 182 | |
| QMSP | 5 | 44.33 (22.23 - 88.39) | 0.0%; 0.878 | < 0.001 | 779 | 541 |
MSP: methylation-specific polymerase chain reaction; QMSP: quantitative methylation-specific polymerase chain reaction; OR: odds ratios; 95% CI: 95% confidence interval.