. 2017 May 22;8(37):61305–61317. doi: 10.18632/oncotarget.18064

Table 4. Stratification analysis for associations between PI3K/AKT/mTOR variants and prostate cancer risk in Chinese men.

Variables	mTOR rs17036508		Adjusted	P^a	P^hom	mTOR rs2295080		Adjusted	P^a	P^hom	Raptor rs1468033		Adjusted	P^a	P^hom	AKT2 rs7250897		Adjusted	P^a	P^hom
	(Cases/Controls)		OR (95%CI)^a			(Cases/Controls)		OR (95%CI)^a			(Cases/Controls)		OR (95%CI)^a			(Cases/Controls)		OR (95%CI)^a
By DOM	CT+CC	TT				GT+GG	TT				AG+AA	GG				CT+CC	TT
Age, yr (median)
≤71	53/69	118/274	1.81 (1.19-2.77)	0.006	0.032	158/329	13/14	0.54 (0.25-1.19)	0.127	0.741	102/180	69/163	1.38(0.94-2.01)	0.097	0.227	82/191	89/152	0.76 (0.52-1.10)	0.145	<0.001
>71	66/128	176/336	1.02 (0.72-1.45)	0.926		223/441	19/23	0.60 (0.32-1.14)	0.120		146/212	96/252	1.81(1.31-2.48)	<0.001		150/219	92/245	1.83 (1.33-2.52)	<0.001
BMI, kg/m²
≤24	63/105	154/296	1.23 (0.85-1.79)	0.280	0.536	203/382	14/19	0.70 (0.34-1.45)	0.339	0.366	123/203	94/198	1.25(0.89-1.75)	0.196	0.062	114/212	103/189	0.99 (0.71-1.39)	0.959	0.051
>24	56/92	140/314	1.36 (0.93-1.01)	0.117		178/388	18/18	0.43 (0.22-0.86)	0.016		125/189	71/217	2.02(1.42-2.87)	<0.001		118/198	78/208	1.58 (1.12-2.24)	0.010
Smoking status
Never	50/80	140/273	1.22 (0.81-1.84)	0.341	0.835	179/335	11/18	0.87 (0.40-1.89)	0.728	0.152	113/169	77/184	1.61(1.12-2.30)	0.009	0.982	102/171	88/182	1.24 (0.87-1.77)	0.231	0.938
Ever	69/117	154/337	1.34 (0.94-1.92)	0.109		202/435	21/19	0.42 (0.22-0.80)	0.008		135/223	88/231	1.58(1.13-2.19)	0.007		130/239	93/215	1.24 (0.89-1.72)	0.206
Ethnic group
Han	24/52	68/156	1.12 (0.63-1.97)	0.703	0.504	82/194	10/14	0.61 (0.26-1.45)	0.266	0.871	51/96	41/112	1.44(0.87-2.36)	0.155	0.693	51/94	41/114	1.52 (0.92-2.51)	0.099	0.358
Uygur	95/145	226/454	1.33 (0.98-1.81)	0.068		299/576	22/23	0.56 (0.30-1.02)	0.057		197/296	124/303	1.66(1.26-2.20)	<0.001		181/316	140/283	1.18 (0.90-1.56)	0.237
Variables	*mTOR* rs17036508		Adjusted	P^a	P^hom	*mTOR* rs2295080		Adjusted	P^a	P^hom	*Raptor* rs1468033		Adjusted	P^a	P^hom	*AKT2* rs7250897		Adjusted	P^a	P^hom
	(Cases/Controls)		OR (95%CI)^a			(Cases/Controls)		OR (95%CI)^a			(Cases/Controls)		OR (95%CI)^a			(Cases/Controls)		OR (95%CI)^a
by REM	CC	TT+CT				GG	TT+GT				AA	GG+AG				CC	TT+CT
Age, yr (median)
≤71	157/337	14/6	4.75 (1.78-12.71)	0.002	0.854	81/128	90/215	0.67 (0.46-0.97)	0.035	0.002	158/318	13/25	1.19(0.54-2.42)	0.635	0.882	154/303	17/40	0.89 (0.49-1.63)	0.710	0.577
>71	231/459	11/5	4.88 (1.65-14.38)	0.004		96/225	146/239	1.46 (1.06-2.00)	0.021		224/433	18/31	1.34(0.72-2.49)	0.351		217/418	25/46	1.05 (0.62-1.76)	0.858
BMI, kg/m²
≤24	206/394	11/7	3.20 (1.20-8.53)	0.020	0.210	90/176	127/225	1.09 (0.78-1.53)	0.622	0.592	200/351	17/50	0.66(0.37-1.18)	0.163	<0.001	193/352	24/49	0.89 (0.53-1.51)	0.674	0.943
>24	182/402	14/4	8.11 (2.62-25.11)	<0.001		87/177	109/229	0.97 (0.69-1.37)	0.859		182/400	14/6	5.13(1.94-13.6)	0.001		178/369	18/37	0.99 (0.55-1.80)	0.985
Smoking status
Never	182/348	8/5	3.01 (0.97-9.34)	0.057	0.352	81/157	109/196	1.08 (0.76-1.55)	0.663	0.775	180/333	10/20	0.94(0.43-2.07)	0.884	0.588	170/319	20/34	1.11 (0.62-1.99)	0.729	0.507
Ever	206/448	17/6	6.39 (2.46-16.60)	<0.001		96/196	127/258	1.00 (0.72-1.39)	0.987		202/418	21/36	1.45(0.82-2.59)	0.206		201/402	22/52	0.86 (0.51-1.47)	0.589
Ethnic group
Han	87/205	5/3	3.90 (0.90-16.98)	0.069	0.794	37/89	55/119	1.08 (0.65-1.78)	0.778	0.764	85/191	7/17	1.10(0.43-2.80)	0.848	0.675	84/188	8/20	0.95 (0.40-2.26)	0.902	0.893
Uygur	301/591	20/8	5.09 (2.20-11.78)	<0.001		140/264	181/335	1.05 (0.79-1.38)	0.747		297/560	24/39	1.34(0.78-2.30)	0.284		287/533	34/66	0.99 (0.63-1.53)	0.946

BMI: body mass index. ^a Obtained under dominant models in logistic regression analyses with adjustment for age, smoking status and BMI. ^b,c According to the current WHO recommendations.

P^homP value for homogeneiy test. DOM: dominant genetic model; REM: recessive genetic model.

The results were in bold, if P<0.05.