Table 6. False-positive report probability values for associations between the PCa risk and the frequency of Genotypes of PI3K/AKT/mTOR variants.

Genotype	Crude OR (95%CI)	Pa	Statistical powerb	Prior probability
				0.25	0.1	0.01	0.001	0.0001
All patients
mTOR rs17036508 CC vs TT	3.71(1.76-7.84)	0.0006	0.008	0.18	0.397	0.879	0.986	0.999
mTOR rs17036508 CC vs CT/TT	3.68(1.74-7.76)	0.0003	0.005	0.15	0.345	0.853	0.983	0.998
mTOR rs2295080 GT vs TT	0.53(0.32-0.89)	0.0484	0.862	0.144	0.336	0.848	0.982	0.998
mTOR rs2295080 GG/GT vs TT	0.57(0.35-0.93)	0.0236	0.829	0.079	0.204	0.738	0.966	0.997
raptor rs1468033 AG vs GG	1.62(1.27-2.08)	0.0006	0.415	0.004	0.013	0.125	0.591	0.935
raptor rs1468033 AA/AG vs GG	1.59(1.25-2.02)	0.0001	0.284	0.001	0.003	0.034	0.26	0.779
mTOR rs17036508
Age≤71 yrs, CT/CC vs TT	1.69(1.11-2.57)	0.0143	0.363	0.106	0.262	0.796	0.975	0.997
Age≤71 yrs, CC vs CT/CC	4.24(1.56-11.50)	0.0022	0.61	0.011	0.031	0.263	0.783	0.973
Age>71 yrs,CC vs CT/CC	3.14(1.02-9.69)	0.0366	0.876	0.111	0.273	0.805	0.977	0.998
BMI<=24,CC vs CT/CC	2.72(1.02-7.24)	0.0378	0.896	0.112	0.275	0.807	0.977	0.998
BMI>24,CC vs CT/CC	5.40(1.67-17.45)	0.0017	0.571	0.009	0.026	0.228	0.748	0.968
Ever smoking, CC vs CT/TT	4.62(1.73-12.33)	0.0008	0.457	0.005	0.016	0.148	0.636	0.946
uygur, CC vs CT/TT	4.39(1.89-10.21)	0.0002	0.160	0.004	0.011	0.110	0.555	0.926
mTOR rs2295080
BMI>24, GG/GT vs TT	0.46(0.23-0.90)	0.0213	0.833	0.071	0.187	0.717	0.962	0.996
Ever smoking, GG/GT vs TT	0.42(0.22-0.80)	0.0067	0.722	0.027	0.077	0.479	0.903	0.989
Age≤71 yrs, GG vs GT/TT	0.66(0.46-0.96)	0.0288	0.504	0.146	0.34	0.85	0.983	0.998
Age>71 yrs, GG vs GT/TT	1.43(1.04-1.96)	0.0255	0.817	0.086	0.219	0.755	0.969	0.997
Raptor rs1468033
Age>71 yrs, AA/AG vs GG	1.81(1.32-2.48)	0.0002	0.276	0.002	0.006	0.067	0.42	0.879
BMI>24, AA/AG vs GG	2.02(1.42-2.87)	<0.0001	0.198	0.002	0.005	0.048	0.335	0.835
Ever smoking, AA/AG vs GG	1.59(1.15-2.20)	0.0051	0.547	0.027	0.077	0.48	0.903	0.989
Never smoking, AA/AG vs GG	1.60(1.12-2.28)	0.0099	0.712	0.040	0.111	0.579	0.933	0.993
Uygur group, AA/AG vs GG	1.63(1.23-2.14)	0.0005	0.433	0.003	0.010	0.103	0.536	0.920
BMI>24, AA vs AG/GG	5.13(1.94-13.56)	0.0003	0.382	0.002	0.007	0.072	0.440	0.887
AKT2 rs7250897
Age>71 yrs, CT/CC vs TT	1.82(1.33-2.51)	0.0002	0.284	0.002	0.006	0.065	0.413	0.876
BMI>24, CT/CC vs TT	1.60(1.12-2.25)	0.0085	0.662	0.037	0.104	0.56	0.928	0.992
Combined effect (risk genotype)
0 vs >=1	2.46(1.65-3.67)	<0.0001	0.050	0.006	0.018	0.165	0.666	0.952

OR: odds ratio; CI: confidence interval; BMI: body mass index.

^aChi-square test was used to calculate the genotype frequency distributions.

^bStatistical power was calculated using the number of observations in the subgroup and the OR and P values in this table.

The results in false-positive report probability analysis were in bold, if the prior probability < 0.2.