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. 2017 Jun 27;8(37):61528–61537. doi: 10.18632/oncotarget.18616

Figure 3. SDC2 overexpression increased ERK and PI3K activation and cell migration in melanoma cells.

Figure 3

(A) Transfection of SDC2 expression construct overexpress SDC2 mRNA and proteins, while transfection of SDC2-specific shRNA suppress those in melanoma cells as investigated by PCR and western blot. Data were mean ±S.E. (n=3) **, p < 0.01. (B) Phosphorylations of ERK and PI3K, but not of Akt increased upon SDC2 overexpression or decreased by SDC2-specific shRNA transfection. (C) SDC2-overexpressed melanoma cells showed higher migratory ability under adhesion or suspension. SDC2-supressed melanoma cells showed the opposite results. Data were mean ±S.E. (n=5).