Table 1. Demographic data and frequency of CVA in patients with and without ADPKD.
| ADPKD (N = 2647) |
Non-ADPKD* (N = 26470) |
P-valuea | |||
|---|---|---|---|---|---|
| No. | % | No. | % | ||
| Gender | 1.00 | ||||
| Female | 1362 | 51.45 | 13620 | 51.45 | |
| Male | 1285 | 48.55 | 12850 | 48.55 | |
| Age | 1.00 | ||||
| 18-39 | 808 | 30.53 | 8080 | 30.53 | |
| 40-65 | 1582 | 59.77 | 15820 | 59.77 | |
| >65 | 257 | 9.71 | 2570 | 9.71 | |
| Median age (IQR) | 46 (37-55) | 46 (37-55) | |||
| Medical diseases | |||||
| Hypertension | 2230 | 84.25 | 9764 | 36.89 | <.0001 |
| Diabetes mellitus | 470 | 17.76 | 5085 | 19.21 | 0.069 |
| Dyslipidemia | 1102 | 41.63 | 7862 | 29.70 | <.0001 |
| Gout | 834 | 31.51 | 3656 | 13.81 | <.0001 |
| Cardiac dysrhythmia | 436 | 16.47 | 2890 | 10.92 | <.0001 |
| Atrial fibrillation | 90 | 3.40 | 516 | 1.95 | <.0001 |
| Chronic ischemic heart disease | 759 | 28.67 | 4618 | 17.45 | <.0001 |
| Heart failure | 327 | 12.35 | 1306 | 4.93 | <.0001 |
| Peripheral vascular disease | 209 | 7.90 | 1135 | 4.29 | <.0001 |
| Chronic kidney disease | 1572 | 59.39 | 908 | 3.43 | <.0001 |
| Medications | |||||
| RAAS blockade | <.0001 | ||||
| No | 1052 | 39.74 | 21474 | 81.13 | |
| Yes | 1595 | 60.26 | 4996 | 18.87 | |
| Statin | <.0001 | ||||
| No | 1945 | 73.48 | 22841 | 86.29 | |
| Yes | 702 | 26.52 | 3629 | 13.71 | |
| CVA | 231 | 8.73 | 1041 | 3.93 | <.0001 |
| Hemorrhagic stroke | 119 | 4.48 | 245 | 0.92 | <.0001 |
| Subarachnoid hemorrhage | 36 | 1.36 | 30 | 0.11 | <.0001 |
| Intracranial hemorrhage | 95 | 3.59 | 216 | 0.82 | <.0001 |
| Ischemic stroke | 134 | 5.04 | 860 | 3.23 | <.0001 |
*Control group (non-ADPKD group) was matched by age, sex, taxable income and urbanization level.
aChi-square test for categorical variables.
CVA = cerebrovascular accident, ADPKD = autosomal-dominant polycystic kidney disease,
IQR = interquartile range, RAAS = renin-angiotensin-aldosterone system.