Table 4. Cox proportional hazard regression analysis for the risk of CVA in patients with ADPKD.

	Univariate		Multivariate*
	HR	95% CI	HR	95% CI
Gender
Female	1.00		1.00
Male	1.34	1.03 - 1.73	1.36	1.04 - 1.77
Age
18-39	1.00		1.00
40-65	2.12	1.49 - 3.01	1.89	1.31 - 2.73
>65	4.48	2.88 - 6.97	3.30	2.08 - 5.25
Medical diseases
Hypertension	2.63	1.50 - 4.60	3.88	2.16 - 6.96
Diabetes mellitus	1.21	0.88 - 1.66	1.12	0.80 - 1.55
Dyslipidemia	0.64	0.49 - 0.85	0.77	0.57 - 1.05
Medications
No RAASb & statin	1.00		1.00
Statin alone	0.52	0.30-0.91	0.44	0.24-0.79
RAASb alone	0.49	0.37-0.65	0.37	0.28-0.50
RAASb & statin	0.23	0.15-0.37	0.19	0.11-0.31

*Multivariate analysis was done with adjustment for age, gender, hypertension, diabetes,

dyslipidemia and medications.

CVA = cerebrovascular accident, ADPKD = autosomal-dominant polycystic kidney disease,

HR = hazard ratio, CI = confidence interval,

RAASb = renin-angiotensin-aldosterone system blockade.