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. 2017 Jun 27;8(37):61674–61686. doi: 10.18632/oncotarget.18669

Figure 6. Knockdown of IGFBP-2 suppresses tumor growth and enhances the anti-tumor properties of gemcitabine.

Figure 6

(A) The nude mice of the NC group, the sh-IGFBP2 group, the NC + GEM group and the sh-IGFBP2 + GEM group were bioluminescent imaged at the day of 7, 14, 21, 28 and 35. Representative bioluminescence images of each group are shown. (B) The average volumes of orthotopic tumors in the NC group, the sh-IGFBP2 group, the NC + GEM group and the sh-IGFBP2 + GEM group were recorded after 35 days. (C) The mice were sacrificed and pancreases were excised at day 35. Representative images of orthotopic tumors are shown above and the weight of tumors is shown on the right. (D) Immunohistochemical staining was performed to detect the expression of Ki67 for cell proliferation in tumor tissues. NC, infected with negative lentivirus (Original mignification, 20×). Date was presented as the means ± SD for three independent experiments. *** P<0.001.