Table 1. Cox regression analysis for clinical-pathological parameters and biomarkers in combined PCa1 and PCa2 cohort.

Parameter	Univariate			Multivariate
	Hazard ratio [95% CI]	P-value	Model’s P-value	Hazard ratio [95% CI]	P-value	Model’s P-value
Tumor stage (pT3 vs pT2)	4.28 [2.11; 8.65]	<0.001	<0.001	2.81 [1.34; 5.88]	0.006	<0.001
ISUP Gleason grading group	5.15 [2.48; 10.70]	<0.001	<0.001	2.67 [1.21; 5.91]	0.015
Preoperative PSA	1.02 [1.00; 1.04]	0.062	0.106	backward eliminated
MT1E expression	0.59 [0.48; 0.72]	<0.001	<0.001	0.68 [0.55; 0.85]	0.001
GPR52 expression	0.78 [0.54; 1.13]	0.186	0.187	backward eliminated
EZH2 expression	1.66 [1.19; 2.31]	0.003	0.003	backward eliminated
OLR1 expression	1.21 [1.04; 1.40]	0.013	0.012	backward eliminated
HPN expression	0.76 [0.59; 0.98]	0.031	0.031	backward eliminated

Significant P-values are in bold ISUP – International Society of Urological Pathology, PSA – prostate-specific antigen, CI – confidence interval.