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. 2017 Jun 28;8(37):61944–61957. doi: 10.18632/oncotarget.18734

Figure 3. SRPK1 promoted proliferation and invasion of gastric cancer cell lines.

Figure 3

(A) Western blot results showed that SRPK1 expression was higher in gastric adenocarcinoma cells (SUN-1 and AGS cells) than normal gastric epithelial cells (GES-1 cells). (B) Transfection efficiency of SRPK1 overexpression (o/e) and knockdown in both SUN-1 and AGS cells were confirmed. The proliferation (C, D) and invasion (E, F) capacities of tumor cells were tested by CCK-8 and Matrigel-Transwell assays, respectively. Both the cell viability and invasion were up-regulated upon SRPK1 overexpression, whereas SRPK1-siRNA impaired the oncogenic characteristics.