Table 1. G9a expression in epithelial cells of normal cervix, cancer precursors and invasive carcinoma of the uterine cervix.
| Characteristics | Case no. or mean ± SD | G9a (%) | p-value | |||
|---|---|---|---|---|---|---|
| Negative | Positive | |||||
| 1 | 2 | 3 | ||||
| Total cases | 443 | 269 (60.7%) | 80 (18.1%) | 60 (13.5%) | 34 (7.7%) | |
| Age | 46.2 ± 10.1 | 47.7 ± 9.9 | 43.9 ±10.4* | 43.8 ± 9.9* | 44.8 ± 9.9 | 0.003* |
| Histological diagnosis | < 0.0001#,¶ | |||||
| Normal cervix | 148 | 124 (83.8%) | 19 (12.8%) | 5 (3.4%) | 0 | |
| Cancer precursors | 109 | 76 (69.7%) | 27 (24.8%) | 6 (5.5%) | 0 | |
| Invasive carcinoma | 186 | 69 (37.1%) | 34 (18.3%) | 49 (26.3%) | 34 (18.3%) | |
| Tumor stage† | NS#,¶ | |||||
| Stage I | 161 | 58 (36.0%) | 30 (18.6%) | 43 (26.7%) | 30 (18.6%) | |
| Stage II | 25 | 11 (44.0%) | 4 (16.0%) | 6 (24.0%) | 4 (16.0%) | |
| Tumor cell type† | NS##,¶ | |||||
| Squamous cell carcinoma | 151 | 54 (35.8%) | 28 (18.5%) | 39 (25.8%) | 30 (19.9%) | |
| Adenocarcinoma | 35 | 15 (42.9%) | 6 (17.1%) | 10 (28.6%) | 4 (11.4%) | |
| Tumor cell differentiation†,§ | NS#,¶ | |||||
| Well differentiated | 12 | 2 (16.7%) | 2 (16.7%) | 4 (33.3%) | 4 (33.3%) | |
| Moderately differentiated | 67 | 26 (38.8%) | 9 (13.4%) | 23 (34.3%) | 9 (13.4%) | |
| Poorly differentiated | 94 | 35 (37.2%) | 21 (22.3%) | 21 (22.3%) | 17 (18.1%) | |
*ANOVA with post hoc Dunnett’s test compared to G9a negative. #Chi-square test for trend. ¶Chi-square test after regrouping G9a as negative and positive expressions. †invasive carcinoma. ##Chi-square test. §information not provided in 13 cases. NS: non-significant.