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. 2017 Jul 8;8(37):62120–62130. doi: 10.18632/oncotarget.19097

Figure 4. The effect of Notch-1 overexpression on cell growth, apoptosis, and invasion.

Figure 4

(A) CellTiter-Glo® luminescence assay was described the effect of Notch-1 overexpression in combination with rottlerin treatment on nasopharyngeal carcinoma cell proliferation. CNE1: 1μM rottlerin; CNE2: 2μM rottlerin. Control: pcDNA 3.1; cDNA: Notch-1 cDNA; Both: cDNA + rottlerin. *P < 0.05, **P < 0.01, compared with control; #P < 0.05, compared with rottlerin treatment alone or Notch-1 cDNA transfection alone. (B) FACS was conducted to investigate cell apoptosis in nasopharyngeal carcinoma cells after Notch-1 cDNA transfection and rottlerin treatment. (C) Left panel: Invasion assay was performed in CNE1 and CNE2 cells after Notch-1 cDNA transfection and rottlerin treatment. Right panel: Quantitative results are illustrated for left panel.