Figure 5. miR-217 directly regulates AEG-1 and PD-L1 in Hep2 cells.
(A) Prediction of miR-217 binding sites on AEG-1 and PD-L1. (B) Prediction of miR-217 mutant binding sites on AEG-1 and PD-L1. (C) Luciferase activity in Hep2 cells infected with miR-217 or control after transfection with the indicated 3′-UTR-driven reporter plasmid or mutant 3′-UTR-driven reporter plasmid (N=3). (D) Real-time PCR results for endogenous AEG-1 and PD-L1 infected with miR-217 or NC (N=3). (E) Western blot results for endogenous AEG-1 and PD-L1 infected with miR-217 or NC.