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. 2017 Jul 10;8(37):62195–62207. doi: 10.18632/oncotarget.19150

Figure 1. Upregulation of miR-135b-5p in PDAC and its clinical implications.

Figure 1

(A) Expression of miR-135b-5p in 36 cases of fresh human PDAC tissues and matched adjacent normal tissues by real-time PCR analyses. Patient serial numbers were ranked according to the relative expression of miR-135b-5p, and those ranked in the top 50% in terms of expression level were considered to have high expression. (B) The level of miR-135b-5p correlated with the level of SFRP4 mRNA; an exponential regression was observed between them. (C) The level of overexpressed miR-135b-5p was related to higher PET-CT SUVmax values (Mann-Whitney U test, mean ± SEM; *P < 0.05). (D) Forest plot of miR-135b-5p, PET-CT SUVmax values, regional lymph node metastases, vascular invasion and tumor microthrombus as independent predictors of overall survival in patients with resectable PDAC. (E) Overexpression of miR-135b-5p correlated with overall survival in patients with resectable PDAC according to univariate analyses.