Table 2. Univariate and multivariate Cox regression analysis for evaluating the influence of marital status on OS and esophageal cancer CSS in 15598 unmatched cohort with esophageal cancer in SEER database.
| Variable | OS | CSS | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||||
| HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | |
| Marriage | ||||||||
| Married | Reference | Reference | Reference | Reference | ||||
| Unmarried | 1.28 (1.24-1.33) | <0.001 | 1.22 (1.18-1.27) | <0.001 | 1.26 (1.21-1.31) | <0.001 | 1.21 (1.16-1.26) | <0.001 |
| Sex | ||||||||
| Male | Reference | Reference | Reference | Reference | ||||
| Female | 0.99 (0.95-1.04) | 0.854 | 0.86 (0.82-0.90) | <0.001 | 1.00 (0.95-1.05) | 0.950 | 0.88 (0.84-0.93) | <0.001 |
| Race | ||||||||
| White | Reference | Reference | Reference | Reference | ||||
| Black | 1.32 (1.24-1.40) | <0.001 | 1.16 (1.09-1.24) | <0.001 | 1.30 (1.22-1.38) | <0.001 | 1.15 (1.07-1.23) | <0.001 |
| Other race | 1.01 (0.93-1.10) | 0.763 | 0.94 (0.86-1.02) | 0.154 | 1.01 (0.92-1.11) | 0.823 | 0.94 (0.86-1.03) | 0.218 |
| Age | ||||||||
| (<40) vs (41-55) vs (56-70) vs (71-85) vs (>85) | 1.21 (1.18-1.24) | <0.001 | 1.19 (1.16-1.22) | <0.001 | 1.16 (1.14-1.19) | <0.001 | 1.16 (1.14-1.19) | <0.001 |
| Histology | ||||||||
| ESCC | Reference | Reference | Reference | Reference | ||||
| EAC | 0.84 (0.81-0.88) | <0.001 | 0.99 (0.93-1.05) | 0.649 | 0.86 (0.82-0.9) | <0.001 | 0.86 (0.82-0.9) | <0.001 |
| Others | 1.14 (1.06-1.22) | <0.001 | 1.14 (1.05-1.24) | 0.001 | 1.17 (1.10-1.27) | <0.001 | 1.17 (1.10-1.27) | <0.001 |
| Grade | ||||||||
| I vs II vs III vs IV | 1.30 (1.27-1.34) | <0.001 | 1.17 (1.14-1.21) | <0.001 | 1.36 (1.31-1.40) | <0.001 | 1.21 (1.17-1.25) | <0.001 |
| Location | ||||||||
| Upper third of esophagus | Reference | Reference | Reference | Reference | ||||
| Middle third of esophagus | 1.03 (0.95-1.11) | 0.517 | 1.15 (1.07-1.25) | <0.001 | 1.03 (0.95-1.13) | 0.373 | 1.17 (1.07-1.27) | 0.001 |
| Lower third of esophagus | 0.90 (0.84-0.97) | 0.007 | 1.13 (1.04-1.23) | 0.003 | 0.93 (0.86-1.01) | 0.080 | 1.14 (1.04-1.24) | 0.004 |
| TNM Stage | ||||||||
| I vs II vs III vs IV | 1.55 (1.52-1.58) | <0.001 | 1.38 (1.36-1.41) | <0.001 | 1.65 (1.62-1.69) | <0.001 | 1.46 (1.43-1.49) | <0.001 |
| Therapy | ||||||||
| Surgery and radiotherapy | Reference | Reference | Reference | Reference | ||||
| Only surgery | 0.80 (0.74-0.86) | <0.001 | 1.01 (0.94-1.03) | 0.445 | 0.74 (0.68-0.81) | <0.001 | 0.99 (0.91-1.08) | 0.817 |
| Only radiotherapy | 2.08 (1.84-2.35) | <0.001 | 1.63 (1.44-1.85) | <0.001 | 2.22 (1.95-2.53) | <0.001 | 1.68 (1.48-1.92) | <0.001 |
| No surgery or radiotherapy | 2.94 (2.79-3.09) | <0.001 | 2.44 (2.31-2.57) | <0.001 | 3.04 (2.87-3.21) | <0.001 | 2.49 (2.35-2.64) | <0.001 |
SEER=surveillance, epidemiology and end results; OS=overall survival; CSS=cause-specific survival; ESCC=esophageal squamous cell carcinoma; EAC=esophageal adenocarcinoma; TNM= tumor, node and metastasis.