Table 7. Hazard ratios of CSS predictors in AML patients with different marital status, based on multivariate analysis (matched and unmatched complete datasets).
| Variable | Unmarried vs. married matched | Unmarried vs. married unmatched | Never married vs. married matched | Never married vs. married unmatched | ||||
|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | |
| Age (> 55 vs. 16-55 years) | 2.438 (2.358-2.522) | <0.001 | 2.290 (2.223-2.359) | <0.001 | 1.611 (1.529-1.698) | <0.001 | 2.165 (2.094-2.237) | <0.001 |
| Race Black White Other Unknown |
0.946 (0.898-0.998) Reference 0.920 (0.872-0.971) 0.531 (0.335-0.844) |
0.041 0.002 0.007 |
1.003 (0.959-1.048) Reference 1.013 (0.969-1.058) 0.776 (0.567-1.062) |
0.912 0.574 0.113 |
1.549 (1.449-1.656) Reference 1.018 (0.931-1.114) 0.778 (0.461-1.315) |
<0.001 0.692 0.349 |
1.030 (0.976-1.087) Reference 1.053 (1.002-1.106) 0.750 (0.521-1.079) |
0.285 0.041 0.121 |
| Sex (Male vs. Female) | 1.012 (0.984-1.040) | 0.420 | 1.036 (1.012-1.061) | 0.004 | 1.117 (1.062-1.176) | <0.001 | 1.160 (1.126-1.194) | <0.001 |
| AML subtype (Others vs. AML, NOS) | 0.741 (0.720-0.763) | <0.001 | 0.725 (0.708-0.744) | <0.001 | 0.958 (0.910-1.008) | 0.102 | 0.733 (0.712-0.754) | <0.001 |
| Adjuvant therapy None Radiation Unknown |
Reference 0.683 (0.627-0.743) 1.172 (0.966-1.418) |
<0.001 0.101 |
Reference 0.693 (0.646-0.743) 1.215 (1.038-1.422) |
<0.001 0.016 |
Reference 0.844 (0.755-0.944) 1.286 (0.861-1.921) |
0.003 0.219 |
Reference 0.716 (0.664-0.771) 1.162 (0.948-1.425) |
<0.001 0.149 |
Abbreviation: CSS, cancer-specific death; HR, hazard ratio; CI, confidence interval; AML, acute myeloid leukemia; NOS, no other specific.