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. 2017 May 9;8(37):62716–62729. doi: 10.18632/oncotarget.17698

Table 2. Different techniques for detecting chromosomal aberrations in MDS.

Technique Application Advantage Shortcoming Price
MC visible chromosomal aberrations Simple, whole chromosomal view Low resolution, Can’t detect UPD 800 rmb
FISH small and hidden chromosomal aberrations Not rely on proliferating cells, High sensitivity only detect particular chromosomal aberrations 2000 rmb
SKY Unknown and complex chromosomal aberrations display better pictures of karyotypes Can’t detect structural aberration, low resolution 3500 rmb
SNP-A Cryptic and complex chromosomal aberrations high-resolution, can detect UPD Can’t detect balanced translocation and inversion 5000 rmb
Array-CGH Detect CNV and UPD genome-wide analysis high-resolution Can’t detect balanced rearrangements, low-level mosaicism and polyploidy 4500 rmb
Sequencing CNV and structural variants, unknown mutation or aberrations genome-wide analysis improved sensitivity monitor clonal mutations Expensive, time-consuming, complicated bioinformatic analysis 6000 rmb