. Author manuscript; available in PMC: 2017 Sep 27.

Published in final edited form as: Lancet Infect Dis. 2015 Dec 23;16(3):331–338. doi: 10.1016/S1473-3099(15)00489-2

Table 4.

Features of acute Ebola virus disease associated with sequelae: multivariable analyses

	Uveitis		Any ocular symptom of diagnoses¹		Any auditory symptom²		Arthralgias²

	OR (95% CI)	p	OR (95% CI)	p	OR (95% CI)	p	OR (95% CI)	p
Female (vs. male)	1·73 (0·73–4·09)	0·21	1·57 (0·81–3·07)	0·18	1·09 (0·53–2·23)	0·82	0·94 (0·47–1·87)	0·86
Age in years³	1·08 (0·92–1·26)	0·34	1·21 (1·07–1·37)	0·002	1·06 (0·94–1·20)	0·34	1·07 (0·95–1·21)	0·27
Self-reported acute EVD clinical features⁴
Diarrhoea	0·75 (0·28–1·99)	0·56	0·91 (0·41–1·99)	0·81	0·90 (0·39–2·07)	0·81	0·81 (0·35–1·88)	0·62
Red eyes	0·74 (0·30–1·79)	0·50	1·52 (0·73–3·17)	0·26	-	-	-	-
Cycle threshold values at EVD diagnosis (N=190)⁵,⁶	3·33 (1·87–5·91)	<0·0001	3·04 (1·87–4·94)	<0·0001	1·06 (0·68–1·66)	0·80	0·84 (0·55–1·28)	0·41
Duration of acute EVD (N=190)⁵,⁷	1·11 (0·84–1·46)	0·48	1·01 (0·80–1·27)	0·93	1·00 (0·78–1·28)	0·97	0·84 (0·67–1·05)	0·12

EVD (Ebola virus disease). OR (odds ratio).

Symptoms began during ETU stay or after discharge; diagnoses include uveitis or conjunctivitis.

Symptoms began during ETU stay or after discharge.

For every 5-year increase in age

⁴

At anytime during acute EVD illness (before and within Ebola facility, including ETU), self-reported. Fever included history of fever within the 2 days prior to Ebola facility admission or temperature >38.0°C at the time of EVD case-investigation by the surveillance team.

⁵

Restricted to subset of the population with cycle threshold values and data on duration of acute EVD.

⁶

For every 5-point decrease in the cycle threshold value.

⁷

For every increase in 5 days (from symptom onset to first negative EVD RT-PCR during acute EVD infection).