Figure 2. Fetal Flt3Cre⁺ Kras^G12D progenitors initiate a JMML-like disease upon transplantation.

(A) Schematic of FL transplants (n = 12 mutant and 8 control recipients). Analysis of donor cell (B) engraftment and (C) myeloid contribution in peripheral blood. (D and E) Flow cytometric quantification of donor leukocytes in BM and spleens of moribund mutant recipients and control recipients 16 weeks after transplantation. max, maximum. (F) Overall survival following transplantation (statistical analysis by Mantel-Cox test). (G–I) Normalized tissue weights of analyzed animals. *P < 0.05, ^#P < 0.01, and ^§P < 0.001, by unpaired, 2-tailed Student’s t test (B–E and G–I).