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. Author manuscript; available in PMC: 2017 Sep 28.
Published in final edited form as: J Am Chem Soc. 2017 Jun 29;139(27):9203–9212. doi: 10.1021/jacs.7b02716

Figure 4.

Figure 4

Effect of 1 and 2 on the secondary metabolome of S. albus. (A) HPLC-MS base-peak chromatogram analysis of the secondary metabolome of S. albus in response to 1 (blue trace) and 2 (red trace), compared to the DMSO negative control (black trace). (B) Targeted extracted-ion chromatograms for selected products of the sur cluster. The color-coding in each panel is the same as that in panel A. Albucyclone A and acyl-surugamide A are induced, while production of surugamide I is vastly enhanced.