Table 1.
Half-Maximal Inhibitory Concentrations (IC50, μM) for Products of the sur Cluster in Selected Antibacterial, Antifungal, and Cathepsin B Inhibition Assays
| assays | 11 | 12 | 13 | 14 | 15 | 16 | 21 | 22 |
|---|---|---|---|---|---|---|---|---|
| Cathepsin B Inhibition | >100 | 12.4 | 9.0 | >100 | 43.3 | >100 | >100 | a |
| Staphylococcus aureus Newman | >100 | a | a | >100 | 27.4 | a | >100 | >100 |
| Bacillus subtilis 168 | >100 | a | a | >100 | 21.7 | a | >100 | >100 |
| Enterococcus faecalis OG1RF | >100 | a | a | >100 | >100 | a | >100 | >100 |
| Saccharomyces cerevisiae | >100 | a | a | >100 | 3.5 | a | >100 | >100 |
| Saccharomyces pombe | >100 | a | a | >100 | 32.5 | a | >100 | >100 |
| E. coli K12 | >100 | a | a | >100 | >100 | a | >100 | >100 |
| Pseudomonas aeruginosa PAO1 | >100 | a | a | >100 | >100 | a | >100 | >100 |
a
Not determined.