Table VI.

Perceived Risk

Disease	Risk Factor	Genomic Counseling p Value	Actual Risk p Value	Genomic Counseling FDR p Value	Actual Risk FDR p Value
AMD	Family	0.127	0.270	0.372	0.574
	Smoking	0.195	0.968	0.503	1.00
	Variant	0.082	0.814	0.307	0.891
CAD	Diabetes	0.576	0.506	0.744	0.744
	Family	0.234	0.565	0.569	0.744
	Smoking	0.296	0.564	0.600	0.744
	Variant	0.649	0.071	0.811	0.300
DM1	Family	0.101	0.747	0.334	0.882
	Variant	0.043	0.492	0.228	0.744
DM2	BMI	0.467	0.001	0.744	0.043
	Family	0.715	0.067	0.868	0.300
	Variant	0.813	0.010	0.891	0.119
LUP	Family	0.067	0.032	0.300	0.196
	Variant	0.109	0.102	0.346	0.333
MEL	Family	0.249	0.003	0.572	0.051
	Variant	0.077	0.0001	0.307	0.010

Legend:

Survey Question: What do you think is your chance of developing each of the following diseases in your lifetime?

Null hypothesis: genomic counseling and actual risk do not have an influence on a participant’s belief that they will/will not develop the disease

Hemochromatosis (HH) was not included because there were no participants with HFE mutation (the only reported risk factor) that completed follow up.

Prostate cancer (PRO) was not included because the number of participants with a risk factor was too small to estimate using modeling

AMD: Age Related Macular Degeneration

CAD: Coronary Artery Disease

DM1: Type 1 Diabetes

DM2: Type 2 Diabetes

FDR: False Discovery Rate

HH: Hemochromatosis

LUP: Systemic Lupus Erythematosus

MEL: Melanoma

PRO: Prostate cancer