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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Bioorg Med Chem. 2017 Apr 9;25(19):5114–5127. doi: 10.1016/j.bmc.2017.04.005

Scheme 2.

Scheme 2

Reagents and conditions: (a) 7c or 7d, EDCI, HOBt, i-Pr2NEt, CH2Cl2, 25 °C, 16 h, 80%; (b) MeI, NaH, dry THF, 25 °C, 1 h, 68%; (c) LiOH.H2O, THF/MeOH/H2O (3:1:1), 25 °C, 16 h, 99%.