. Author manuscript; available in PMC: 2018 Oct 1.

Published in final edited form as: Bioorg Med Chem. 2017 Apr 9;25(19):5114–5127. doi: 10.1016/j.bmc.2017.04.005

Table 2.

Enzyme inhibitory and antiviral activity of inhibitors 4a–l.

Entry	Inhibitor structure	K_i	IC₅₀^a^,^b
Entry	Inhibitor structure	(nM)
1		30.8	> 1000
2		0.025	69
3		1.61	189
4		0.79	164
5		0.53	221
6		0.76	32
7		0.80	327
8		0.41	33
9		23.6	nt
10		2.50	nt
11		0.49	280
12		0.40	109

Darunavir (1) exhibited K_i = 16 pM, antiviral IC₅₀ = 3.2 nM

nt = not tested.