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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Addict Biol. 2017 Mar 28;23(1):219–229. doi: 10.1111/adb.12504

Figure 6.

Figure 6

Systemic injection of TC-2153 suppressed cocaine prime-induced reinstatement but not post-abstinence context-induced relapse or cue-induced reinstatement. Rats were either injected with TC-2153 (5 mg/kg, i.p.) or vehicle immediately following the final cocaine SA session. Both groups had increased active lever pressing during (A) the PA test following 6 days of forced abstinence as well as (B) during the cue-induced reinstatement test following extinction. There was no effect of TC-2153 on active lever pressing in either test. However, TC-2153 injections suppressed (C) cocaine prime-induced reinstatement (++++p<0.0001, +++p<0.001, +p<0.05 relative to the last 3 days of SA/extinction, ***p<0.001 relative to vehicle).