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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Neurochem Int. 2017 Mar 28;111:82–92. doi: 10.1016/j.neuint.2017.03.017

Figure 7. Chronic NBP treatment attenuated post-TBI depressive behaviors.

Figure 7

In TBI mice received repeated NBP treatments, forced swim test (FST) and open field test (OFT) were performed to examine the effect of NBP on TBI-induced psychological outcomes. A. In the FST, TBI increased immobility time at 3, 14, and 21 days after TBI. NBP treatment significantly reduced the abnormal behavior. * P<0.05 versus sham group by two-way ANOVA followed by Bonferroni correction; # P<0.05 versus TBI group; n=4–7 per group. B and C. In the OFT, the TBI group showed less time in the center and fewer entries into the center area 21 days after TBI. NBP treatment reversed the behavior change. * P<0.05 versus sham group by two-way ANOVA followed by Bonferroni correction; # P<0.05 versus TBI group; n=4–7 per group. D and E. Summarized data of the distance animals travelled and the velocity during the OFT. There was no significant difference among groups. * P<0.05 versus sham group; # P<0.05 versus TBI-saline controls by two-way ANOVA followed by Bonferroni correction; n=4–7 per group.