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Acute (a) or chronic (b) MAMAc dosing regimen in Eker rats and follow-up analyses on gene expression, DNA adduct formation, renal pathology and cell proliferation. Body weights of male (c) and female (d) Eker rats before and after 6 months of MAMAc or vehicle treatment. Data represent means ± SEM. Student's t-tests comparing body weights at either day 0 or day 180 revealed no significant differences between MAMAc and vehicle treated groups.
