Skip to main content
. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Arch Toxicol. 2017 Mar 27;91(10):3427–3438. doi: 10.1007/s00204-017-1953-6

Table 1. Differentially expressed DNA repair genes in Eker and wild type rats.

Gene KEGG pathway Direction of regulation Adjusted p-value
Ssbp1 DNA replication, Homologous recombination, Mismatch repair Up 5.772972e-05
Stra13 Fanconi anemia pathway Up 0.0001458302
Lig3 Base excision repair Down 0.0000180946
Brcc Homologous recombination Up 0.0001258071
Rnaseh2b DNA replication Down 1.007141e-05
Pole4 DNA replication, Nucleotide excision repair, Base excision repair Down 0.000120004
Bre Homologous recombination Down 9.037353e-06
Lig3 Base excision repair Up 0.0008834112

DNA repair genes from selected KEGG pathways with differential expression in vehicle treated Eker rats vs. wild type littermates. P-values were obtained using Limma's moderated F-statistic, which tests the overall significance for each gene and adjusted for multiple testing applying the Benjamini and Hochberg method.