Table 2. Numbers and incidence of pre-neoplastic and neoplastic lesions.
| 3 months treatment | 6 months treatment | |||||||
|---|---|---|---|---|---|---|---|---|
| Male | Female | Male | Female | |||||
| Vehicle | MAMAc | Vehicle | MAMAc | Vehicle | MAMAc | Vehicle | MAMAc | |
| N = 10 | N = 10 | N = 10 | N = 10 | N = 10 | N = 10 | N = 9 | N = 10 | |
| Cortex | ||||||||
| bAT | 34 | 35 | 35 | 53 | 45 | 60 | 28 | 36 |
| bAH | 5 | 6 | 1 | 6 | 11 | 11 | 2 | 5 |
| Medulla | ||||||||
| bAT | 1 | 3 | 0 | 2 | 5 | 5 | 0 | 0 |
| bAH | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
| Papilla | ||||||||
| bAT | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| bAH | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 |
| Total Kidney | ||||||||
| Total # bAT | 35 | 38 | 35 | 55 | 50 | 65 | 28 | 36 |
| Total # bAH | 5 | 6 | 1 | 6 | 11 | 12 | 2 | 7 |
| Total # other ATs | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 1 |
| Total # adenoma | 0 | 1 | 0 | 1 | 0 | 2 | 0 | 1 |
| Total # carcinoma | 1 | 1 | 3 | 0 | 1 | 3 | 1 | 2 |
| Total # all lesions | 41 | 46 | 39 | 62 | 62 | 84 | 31 | 47 |
| Incidence pre-neoplastic lesions | 9 / 10 | 10 / 10 | 10 / 10 | 10 / 10 | 10 / 10 | 10 / 10 | 9 / 9 | 10 / 10 |
| Incidence neoplastic lesions | 1 / 10 | 2 / 10 | 3 / 10 | 1 / 10 | 1 / 10 | 5 / 10 | 1 / 9 | 3 / 10 |
| Incidence all lesions | 9 / 10 | 10 / 10 | 10 / 10 | 10 / 10 | 10 / 10 | 10 / 10 | 9 / 9 | 10 / 10 |
Total numbers of pre-neoplastic and neoplastic lesions in 3 and 6 months MAMAc or vehicle treated male and female Eker rats. bAT: basophilic atypical tubule, bAH: basophilic atypical hyperplasia. Other ATs include atypical tubules with either oncocytic, eosinophilic or chromophobe phenotype. A detailed summary of the statistical analysis is given in the text.