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. Author manuscript; available in PMC: 2018 Sep 28.
Published in final edited form as: J Am Chem Soc. 2017 Mar 28;139(14):5051–5060. doi: 10.1021/jacs.6b11323

Figure 1. Sequence conservation and consensus of the homeodomain family.

Figure 1

A) The sequence logo, where residue height is proportional to degree of conservation, is calculated from the Pfam version 26.0 homeodomain seed sequence from 12/21/2012. B) Sequence alignment of engrailed- and consensus-HDs. Sequence differences are shaded green. Residues that contact DNA are indicated with asterisks. The positions of the three helices in the engrailed-HD are indicated with cylinders. C) Sequence differences (shaded in green with side chains shown) mapped onto the crystal structure of engrailed-HD (PDB: 1ENH).