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. Author manuscript; available in PMC: 2018 Sep 27.
Published in final edited form as: J Am Chem Soc. 2017 Sep 19;139(38):13450–13455. doi: 10.1021/jacs.7b06432

Figure 1.

Figure 1

The pikromycin (Pik) biosynthetic pathway. The macrolactones 10-dml (1) and narbonolide (2) generated by the Pik PKS undergo further tailoring to the macrolides methymycin (3) and pikromycin (4), respectively. KSQ, KS-like domain; KR*, inactive KR.