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. 2017 Sep 27;8:707. doi: 10.1038/s41467-017-00786-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Transgenic expression of human IL-2 enables NOG mice to support viability of TILs. a Changes in IL-2 plasma levels in NOG mice injected with 45,000 U IL-2 over time and steady-state levels of IL-2 in hIL2-NOG mice. b In vivo bioluminescence images over time of two hIL2-NOG transgenic mice with different serum levels of hIL-2 injected with MM33 TILs labeled with a luciferase lentivirus. c Quantification of radiance of luciferase-expressing MM33 TILs growing in mice (from b) with different serum levels of IL-2. d In vivo bioluminescence images from different angles of tumor-bearing or non-tumor-bearing hIL2-NOG transgenic mice injected with luciferase-expressing MM33 TILs. The experiments shown here were performed once