Fig. 3.

Transgenic expression of human IL2 enables TIL-mediated tumor eradication in NOG mice. a Six hIL2-NOG transgenic mice and three NOG mice were transplanted with luciferase labeled MM33 tumor cells. After tumor growth had been confirmed by IVIS imaging, all NOG mice, and three of the hIL2-NOG mice, were injected with autologous REP TILs and tumor growth was measured with calipers. Shown to the right are individual mice. b IVIS imaging to investigate if mice are disease free. Inset, very prolonged exposure yielding mostly spark signals from static electricity. The experiment described here was performed once, follow-up experiments confirming the data are in Fig. 4 and Supplementary Fig. 5