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. 2017 Sep 27;7:12357. doi: 10.1038/s41598-017-10395-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Clinical Description. Pathology of the proband (III-11): (A–C). (A) Transverse colon polyp, low grade intraepithelial neoplasia. (B) Lower and moderately differentiated adenocarcinoma of Upper Rectum, Invade the intestinal wall to the perinatal fat, T3N0. (C) Moderately differentiated adenocarcinoma of Lower Rectum. Pathology of the III-14: (D,E). (D) Transverse colon polyp, tubular adenoma. (E) Polyp of rectum, malignant transformation, moderately differentiated, T3N0. Pathology of the IV-7: (F,G). (F) Rectum, tubular adenoma. (G) Sigmoid colon, low grade tubular adenoma.