Table 2.
Estimated means and difference in estimated means (at t = 0 and time trend) between exacerbation and control group based on linear mixed-effects modela.
| Estimated means (SE) | Estimated mean difference (95%CI) | |||||||
|---|---|---|---|---|---|---|---|---|
| T = −4 | T = −2 | T = 0 | T = 0 | p | Time trend | p | ||
| FEV1%pred | E group | 69.33 (11.52) | 68.58 (11.37) | 67.82 (11.30) | −16.30 (−28.75, −3.85) | 0.012 | 0.067 (−0.232, 0.366) | 0.650 |
| NE group | 87.51 (12.61) | 85.81 (12.25) | 84.12 (12.15) | |||||
| RSS | E group | 2.25 (1.38) | 2.76 (1.35) | 3.27 (1.33) | 2.97 (1.52, 4.42) | <0.001 | 0.051 (0.000, 0.102) | 0.051 |
| NE group | 0.70 (1.54) | 0.50 (1.46) | 0.30 (1.43) | |||||
Abbreviations: E, exacerbation; NE, no exacerbation; FEV1% predicted, forced expiratory volume in 1 second percentage of predicted; RSS, Respiratory Symptom Score. aReference categories: site University Medical Centre Utrecht, female sex, age 10.3 years, exacerbations in 2 years before inclusion, Pseudomonas Aeruginosa at inclusion, season autumn.