Table 1.
Area under the curve (AUC) of the receiver operator characteristic (ROC) curve, sensitivity and specificity of each IgG4-RD characteristic
| Statistically different characteristics | AUC | Cut-off | Sensitivity (%) | Specificity (%) |
| Inflammatory features | ||||
| 1. CRP (mg/dL) | 0.96 | <0.80 | 88.8 | 93.9 |
| 2. Hb (g/dL) | 0.84 | >12.0 | 68.9 | 81.8 |
| 3. Plt (×104/µL) | 0.82 | <28.8 | 84.4 | 75.7 |
| 4. Alb (mg/dL) | 0.88 | >3.4 | 93.1 | 72.7 |
| 5. TP (g/dL) | 0.89 | <8.5 | 90.7 | 87.9 |
| 6. T-Chol (mg/dL) | 0.93 | >156 | 84.4 | 87.9 |
| 7. Soluble IL-2 receptor (U/mL) | 0.82 | <722 | 65.7 | 100 |
| 8. LDH (IU/L) | 0.88 | >144 | 80.0 | 81.3 |
| 9. ESR (mm/hr) | 0.93 | <90 | 93.1 | 94.1 |
| Allergic features | ||||
| 1. Atopic history | 71.1 | 75.7 | ||
| 2. Eosinophil (%) | 0.71 | >4.2 | 52.3 | 90.9 |
| Immunoglobulin patterns | ||||
| 1. IgG (mg/dL) | 0.89 | <3700 | 97.7 | 75.7 |
| 2. IgA (mg/dL) | 0.96 | <330 | 93.2 | 93.9 |
| 3. IgM (mg/dL) | 0.88 | <100 | 72.1 | 90.9 |
| 4. IgG4/IgG (%) | 0.72 | >10.0 | 86.7 | 66.7 |
| Distribution of organ involvements | ||||
| 1. Orbits and lacrimal glands | 75.5 | 97.0 | ||
| 2. Salivary glands | 64.4 | 97.0 | ||
| 3. Pancreas | 22.2 | 100 | ||
| 4. Orbits, lacrimal glands, salivary glands or pancreas | 88.9 | 97.0 | ||
| 5. Non-involvement of lymph nodes | 53.4 | 100 | ||
| 6. Non-involvement of lungs | 73.4 | 54.4 | ||
| 7. Non-involvement of skin | 95.6 | 21.2 | ||
| 8. Non-involvement of spleen | 100 | 48.5 |
Alb, albumin; CRP, C reactive protein; ESR, erythrocyte sedimentation rate; Hb, haemoglobin; LDH, lactate dehydrogenase; Plt, platelet; TP, total protein; T-Chol, total cholesterol.