Figure 2.

Decreased aortic elastic fibre destruction and proteoglycan degradation in Adamts-4−/− mice. (A) Representative images of hematoxylin and eosin (HE) staining and Verhoeff–van Gieson elastin staining (elastin) of ascending aortic sections from unchallenged and challenged WT and Adamts-4−/− mice. Quantification studies showing less elastic fibre fragmentation in aortas from challenged Adamts-4−/− mice than in aortas from challenged WT mice. Western blot analysis (B) and representative immunofluorescence staining images (C) indicating less versican degradation in aortas from challenged Adamts-4−/− mice than in aortas from challenged WT mice.