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. 2017 Sep 27;7:12351. doi: 10.1038/s41598-017-12248-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Decreased macrophage infiltration in the aortas of Adamts-4−/− mice. (A) Representative immunofluorescence staining images showing reduced CD68+ and F4/80+ macrophage infiltration in aortas from challenged Adamts-4−/− mice than in aortas from challenged WT mice. (B) Transwell assay indicating significantly less interleukin (IL)-1–induced invasion of macrophages from Adamts-4−/− mice than macrophages from WT mice.