Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Sep 18;6(3):43. doi: 10.3390/pathogens6030043

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Schematics of HPSE’s role in HPV 16 infection. (1) Mammalian heparanase from surrounding cells or extrinsically added bacterial heparinase III (2) cleaves heparan sulfate proteoglycan (HSPG) chains attached to the surface of HPV16 or (3) reaches the extracellular membrane (ECM) where HPV16 particles attached to the ECM via HSPG are cleaved and released. (4) Released HPV16 viruses are infectious and (5) infect surrounding keratinocytes during a wound healing in vivo model, as shown by Surviladze et al [39].