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. 2017 Sep 20;7(3):39. doi: 10.3390/bios7030039

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Diagnostic accuracy of the paper-based SCA screening test kit. (a) Aggregate confusion matrix for screening of blood samples (n = 185) with characteristic HbS concentrations via visual interpretation (inexperienced users; n = 3) of the blood stains produced on paper by the metabisulfite (MS) formulation of the test (185 samples × 3 users = 555 total scores). (b) Aggregate confusion matrix for the screening of blood samples (n = 143) with characteristic HbS concentrations via visual interpretation (inexperienced users; n = 3) of the blood stains produced on paper by the hydrosulfite (HS) formulation of the test (143 samples × 3 users = 429 total scores). Rows correspond to characteristic genotypes (based on HbS concentration measured using conventional high-performance liquid chromatography—HPLC) and columns correspond to predicted genotypes (diagnosed by the paper-based test). Shaded cells contain the numbers of correct diagnoses.

Diagnostic accuracy of the paper-based SCA screening test kit. (a) Aggregate confusion matrix for screening of blood samples (n = 185) with characteristic HbS concentrations via visual interpretation (inexperienced users; n = 3) of the blood stains produced on paper by the metabisulfite (MS) formulation of the test (185 samples × 3 users = 555 total scores). (b) Aggregate confusion matrix for the screening of blood samples (n = 143) with characteristic HbS concentrations via visual interpretation (inexperienced users; n = 3) of the blood stains produced on paper by the hydrosulfite (HS) formulation of the test (143 samples × 3 users = 429 total scores). Rows correspond to characteristic genotypes (based on HbS concentration measured using conventional high-performance liquid chromatography—HPLC) and columns correspond to predicted genotypes (diagnosed by the paper-based test). Shaded cells contain the numbers of correct diagnoses.