Figure 5.

Measured and calculated electron distributionof the membrane-embedded A${\beta }_{25-35}$ (a) and A${\beta }_{1-42}$ (b) peptides and their position in the membrane. Good agreement between calculations and experiments was obtained for a position of A${\beta }_{25-35}$ in the hydrocarbon membrane core. The peptide takes a slightly tilted orientation, in agreement with computer simulations. The full length A${\beta }_{1-42}$ peptide was also found to embed in anionic lipid membranes. These results exclude a membrane-spanning $\beta$-sheet structure for A$\beta$ monomers, as was reported from Molecular Dynamics simulations [51,54,55]. (Adapted from [49], copyright PLoS ONE, 2014.)